What Is Preimplantation Genetic Testing for Monogenic/Single Gene Defects (PGT-M)?
An embryo that appears healthy can contain genetic mutations. Preimplantation genetic testing for monogenic/single gene defects (formerly known as PGD) provides information that helps to minimize the risk of passing on a serious genetic condition. Couples who are carriers of inherited genetic diseases can consider PGT-M testing to increase the chances of a healthy embryo selection. PGT-M tests for diseases such as:
- Sickle Cell Anemia
- Tay-Sachs Disease
- Cystic Fibrosis
What Is Preimplantation Genetic Testing for Chromosomal Structural Rearrangements (PGT-SR)?
What if I Don’t Know if I Am a Carrier?
As part of RADfertility’s routine initial patient work up, you will be offered testing for certain genetic diseases, in order to develop an appropriate plan of care. If both partners are carriers for specific genetic mutations, PGT-M offers the most appropriate solutions to identify those embryos that lack the familial genetic disease mutations.
Genetic karyotyping, also known as chromosome analysis, is testing that can reveal certain chromosome abnormalities. Karyotypes are done for couples that have an increased risk and if identified, PGT-SR is available.
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Preimplantation genetic testing for aneuploidies (PGT-A) is a tool used to optimize the efficiency of IVF, increasing the likelihood of a successful pregnancy.
PGT-M and PGT-SR
Preimplantation genetic testing for monogenic/single gene defects (PGT-M) and (PGT-SR) are tests that help evaluate embryos for genetic risk factors.
Janet Berman, MS, LCGC
Get to know Janet Berman, MS, LCGC, the Director of Genetic Counseling at RADfertility.
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"I feel so lucky to have found RADfertility. I tried two other clinics before I expanded my search and found RADfertility. I drive an hour each way to go to them but I don’t regret a thing. They are so caring and so professional. Every time I message them they respond quickly. Every time I see them they have a friendly smile and warm welcome. They explain everything so well and I never feel lost in the process as I did elsewhere. They also took the time to figure out what was wrong. Other clinics threw up their hands, said 'I don’t know' and pushed me to try IVF."
"Dr. Feinberg and the entire staff at RADfertility are absolutely amazing. The receptionists, coordinators, nurses, and lab staff are compassionate, caring, and straight forward. I’ve had a 12-year infertility journey and I’ve tried other clinics but RADfertility was the only one I felt at ease with. They answered any questions that I had and were there any time I needed them. My coordinator, Amy, was the absolute best and always had my back. Dr. Feinberg’s dedication to his patients is incredible. You are not just a number there, you are a person with individualized needs and care."
"My journey with RADfertility and Dr. McGuirk started when my husband and I were trying to conceive and were having difficulty. We went to RADfertility, where we met Dr. McGuirk. I always say she changed my life and 'fixed' me. Dr. McGuirk is always learning more about endometriosis and how to help her patients. She’s brilliant and truly cares for you! I’m eternally grateful to her and everyone at RADfertility for their unwavering support, love, and care."
"Every step of our journey was tailored to us. We were treated so respectfully. Every detail was clearly explained and we felt so comfortable. Rhonda Wright was a Godsend and inspiring. I highly recommend this place! I cried when my weekly appointments were done and I 'graduated.'"
"The staff and doctors are amazing. It will feel like home every time you walk in the door. They gifted us with our miracle baby and we couldn’t be happier. I will always recommend RADfertility above all others!"
"RADfertility's staff has heart and provided me with exceptional health care. I knew I was in good hands and felt like we were in this together. The doctors and nursing staff always answered all of my questions and provided thorough information about all of my options. I am so fortunate and appreciative of the care that I received at RADfertility. They go above and beyond."
"I cannot begin to explain how wonderful RADfertility is. We were frustrated with trying to start a family and it not working for us. The entire team of doctors and nurses made us feel comfortable and hopeful that we would be parents. We experienced so many ups and downs but we never felt like we were on our IVF journey alone, we had our RADfertility team every step of the way. If you're looking for a supportive team on the IVF journey, look no further. RADfertility is the absolute best."
"Dr. Schillings always kept us informed and never gave up on us. She always explained our options and risks with each procedure. She called us personally when there were any issues or sensitive subjects to cover. Dr. Schillings was the first doctor that had answers for us and wanted to help us have our miracle baby!"
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